I use an old Roland GP-8 in the F/X loop, for the delay only, set to 300 ms, just enough to hear it.
Duncan JBs and DiMarzio Super Distortions are particularly nice with a 5150, in the bridge of course.
Big rock’n polished studio sound, live! AND at family room volumes!
Eddie’s settings as a start.
6.2 6.6 6.6 2.0 5.0 4.5 4.4 3.5 6.2
pre pre low mid hi mst mst res prs
Crunch switch IN. I haven’t changed much at much. I keep coming back to this sweet spot since 93. I just put the mid on 3 and the resonance and presence both on 7!